PurposeChildhood onset speech fluency disorder is possibly related to dopaminergic dysfunction. Mesencephalic hyperechogenicity detected by transcranial ultrasound might be seen as an indirect marker of dopaminergic dysfunction. We here determined whether adults who stutter since childhood show ME.MethodsWe performed TCS in ten AWS and ten matched adults who never stuttered. We also assessed motor performance in finger tapping and in the 25 Foot Walking test.ResultsCompared to controls, AWS showed enlarged ME on either side. Finger tapping was slower in AWS. Walking (...) cadence, i.e., the ratio of number of steps by time, tended to be higher in AWS than in control participants.DiscussionThe results demonstrate a motor deficit in AWS linked to dopaminergic dysfunction and extending beyond speech. Since iron deposits evolve in childhood and shrink thereafter, ME might serve as an easily quantifiable biomarker helping to predict the risk of persistency in children who stutter. (shrink)

Mit diesem Buch wird erstmals ein umfassendes und systematisches Referenzwerk zu Christian Wolff vorgelegt, das alle wichtigen Aspekte zu Leben und Werk des Philosophen behandelt. Das Handbuch ist von international renommierten Experten verfasst und behandelt neben der Biographie und der philosophiegeschichtlichen Rolle Wolffs sowohl sein philosophisches als auch sein naturwissenschaftlich-mathematisches Werk.

Two distinct attitudes have been adopted by investigators in the field of the sociology of knowledge. One of them may be called speculative; the other, empirical. The central interest of an investigator having the speculative attitude lies in developing a theory of the sociology of knowledge. The central interest of investigators having the empirical attitude lies in finding out or explaining concrete phenomena; the theory is employed, implicitly or explicity, for this purpose. The existence of the two attitudes may be (...) in part explained, as far as the German sociology of knowledge is concerned, by reference to the history of this school, which has grown out of and has been determined by a Marxist and materialistic philosophy, and especially by the use of this philosophy as a political instrument in the struggle of the emerging proletariat against the bourgeoisie. This statement, however, must be supplemented by a short location of the four most important contributors to the theory of the German sociology of knowledge. Max Scheler approaches the problem phenomenologically; he was the first and only one to ask the fundamental question, “What is knowledge?” Karl Mannheim, though markedly influenced by the Marxist viewpoint, particularly by Lukács, seems to me more adequately characterized by stressing his development from a more exclusively speculative to a more decidedly empirical attitude, which latter is especially evident in his most recent book, Man and Society in an Age of Reconstruction. Alexander von Schelting's main contribution is his thorough logical analysis of Mannheim's theory in the light of Max Weber's methodology. Ernst Grünwald has given the most complete survey of the forerunners, the history, and the various contributions of the sociology of knowledge. These four thinkers are indirectly dependent on the historically determined emphasis of the movement on ideology in that they remain on the level of a theoretical discussion without arriving at factual research. (shrink)

Alexander Gottlieb Baumgarten gilt mit Fug und Recht als der selbstandigste aller Wolffianer. Doch hat man kaum je systematisch untersucht, worin - uber die Begrundung der Asthetik hinaus - seine denkerische Originalitat besteht. Im vorliegenden Band wird der fur Kant wichtigste Schulautor als Erkenntnistheoretiker, Psychologe und Moralphilosoph erstmals prononciert aus dem Schatten Wolffs herausgeholt. Nach der jungsten Pionierubersetzung der Metaphysica ins Deutsche folgt hier eine interpretatorisch wegweisende Detailstudie zu philosophischen Schlusselthemen des fruhvollendeten Hochaufklarers - gerade recht zu den anstehenden (...) Jubilaen. Alexander Gottlieb Baumgarten is regarded justifiably as the most independent of all Wolffians. Up to now however there have been very few systematic studies examining his intellectual originality, apart from his founding of aesthetics. In this volume, the author who was most important for Kant during his school years finally steps out of Wolff's shadow and is revealed to be an epistemologist, a psychologist and moral philosopher. After the recent translation of the Metaphysica into German, a pioneering achievement, what follows here is an interpretively groundbreaking detailed study of the key philosophical subjects of the philosopher of the High Enlightenment, just in time for the current anniversaries. (shrink)

Research on the history of ethics has ignored Alexander Gottlieb Baumgarten miserably. And that even though Kant based his lectures on moral philosophy on Baumgarten's text books over the course of decades. This article takes up the cudgels for this "in ethicis" most independent follower of Wolff. In addition to Baumgarten's epistemological elevation of perception, which is known to have resulted in the new foundation of aesthetics as an independent discipline, his reception of two lines of tradition was (...) primarily decisive for an original further development of Wolff's basic approach. First, Baumgarten gave his practical philosophy a strong legal flavor through orienting it toward the natural law theory of his Jena teacher Heinrich Köhler. This legal character can be seen mainly in the then resulting predominance of the concept of obligation. Second, Baumgarten secularized the heritage of pietism in Halle by emphasizing the need for lively perception in order to act morally. Both with his orientation toward an ethics of duty, as well as with his highlighting of motivation, he laid the foundation for Kant's seminal transformations in this field.Die ethikgeschichtliche Forschung hat Alexander Gottlieb Baumgarten bisher sträflich vernachlässigt, obgleich Kant über Jahrzehnte hinweg dessen Handbücher seiner Vorlesung über Moralphilosophie zugrundegelegt hat. Demgegenüber möchte der vorliegende Beitrag eine Lanze für den auch 'in ethicis' selbständigsten Wolffianer brechen. Neben der erkenntnistheoretischen Aufwertung der Sinnlichkeit, die sich bekanntlich in der Neubegründung der Ästhetik als einer eigenen Disziplin niederschlug, war vor allem die Rezeption zweier Traditionslinien für eine originelle Fortentwicklung des Wolffschen Grundansatzes maßgeblich: Zum einen verlieh Baumgarten seiner praktischen Philosophie durch die Orientierung am Naturrecht seines Jenenser Lehrers Heinrich Köhler ein stark juridisches Gepräge, wie dies vor allem an der nunmehrigen Vorherrschaft des Verbindlichkeitsbegriffs abzulesen ist. Zum anderen säkularisierte er das Erbe des Halleschen Pietismus, wenn er etwa die Notwendigkeit lebendiger Erkenntnis für das sittliche Handeln unterstrich. Sowohl mit der pflichtethischen Ausrichtung als auch mit der Akzentuierung des Motivationsproblems hat er Kants epochemachenden Umwälzungen auf diesem Gebiet entscheidend vorgearbeitet. (shrink)

ObjectiveIn this study we used functional magnetic resonance imaging to investigate whether motor imagery of handwriting and circle drawing activates a similar handwriting network as writing and drawing itself.MethodsEighteen healthy right-handed participants wrote the German word “Wellen” and drew continuously circles in a sitting and lying position to capture kinematic handwriting parameters such as velocity, pressure and regularity of hand movements. Afterward, they performed the same tasks during fMRI in a MI and an executed condition.ResultsThe kinematic analysis revealed a general (...) correlation of handwriting parameters during sitting and lying except of pen pressure during drawing. Writing compared to imagined writing was accompanied by an increased activity of the ipsilateral cerebellum and the contralateral sensorimotor cortex. Executed compared to imagined drawing revealed elevated activity of a fronto–parieto-temporal network. By contrasting writing and drawing directly, executed writing induced an enhanced activation of the left somatosensory and premotor area. The comparison of the MI of these tasks revealed a higher involvement of occipital activation during imagined writing.ConclusionThe kinematic results pointed to a high comparability of writing in a vertical and horizontal position. Overall, we observed highly overlapping cortical activity except of a higher involvement of motor control areas during motor execution. The sparse difference between writing and drawing can be explained by highly automatized writing in healthy individuals. (shrink)

Keine ausführliche Beschreibung für "Die Überwindung des mathematischen Erkenntnisideals" verfügbar.

Unter den griechischen exegetischen Werken zu den Schriften des Aristoteles kommt dem von um 200 n. Chr. wirkenden Alexander von Aphrodisias (Bücher 1-5) und einem byzantinischen Gelehrten des 13. Jahrhunderts, bekannt als Pseudo-Alexander, (Bücher 6--?14) stammenden Kommentar zur Metaphysik des Aristoteles eine überragende Bedeutung zu. Der Wert des durch fundierte Kenntnisse der Philosophie des Aristoteles ausgezeichneten Kommentars ist sowohl für die denkerische Durchdringung der aristotelischen Metaphysik als auch für die Geschichte der griechischen Philosophie nicht genug hochzuschätzen. Den Denkern (...) des Mittelalters lag der Text aber nicht vor. Erst im Jahre 1527 machte der berühmte spanische Humanist Juan Ginés de Sepúlveda (1490?-1573) der breiten Öffentlichkeit den Kommentar zur Metaphysik erst zugänglich. Seine immer noch geschätzte, in gewissem Sinne auch unentbehrliche Übersetzung des Kommentars zu den ersten zwölf Büchern erstellte er aufgrund der Kollationierung der ihm zu Gebote stehenden Handschriften mit philologischer Gewissenhaftigkeit und ermöglichte auf diese Weise die immer noch nicht erforschte Rezeption des Textes in den folgenden drei Jahrhunderten bis zur ersten Edition des vollständigen griechischen Originals durch Hermann Bonitz 1847. Ein Nachdruck der 'editio princeps' dieser lateinischen Übersetzung, die 1561 zum fünften und letzten Mal erschienen ist, ist nicht nur ein Akt der antiquarischen Pietät, sondern kommt gerade im digitalen Zeitalter einer Forderung der Forschung nach. (shrink)

Critic, poet and philosopher Friedrich von Schlegel (1772–1829) was a leading figure of German Romanticism. In the two years before his untimely death, he wrote three cycles of lectures intended as part of a larger project to lay the foundations of a new general philosophy. Two of these cycles, 'Philosophie des Lebens' (given in 1827, published 1828) and 'Philosophie des Sprache und des Wortes' (given in December 1828 and published posthumously), are reissued here in an 1847 English translation. The first (...) presents Schlegel's understanding of philosophy as independent of theology or politics, concerned with the 'inner spiritual life' of humankind. The second explores the nature of communication through language and art. Schlegel argues that full human consciousness cannot be restored by Enlightenment science, but only by divine revelation and redemption. He offers no ready-made solutions, but encourages his listeners to develop their own responses to these questions. (shrink)

The article introduces the pedagogical background and impact of Grue-Sørensen. Knud Grue-Sørensen came to educational science from philosophy and was infl uenced by Kantian philosopher Leonard Nelson. Grue-Sørensen became the first professor of education at the University of Copenhagen. During an era in which research in the fi eld of education became more and more infl uenced by empirical research, Grue- Sørensen held on to a theoretically and historically rooted pedagogy. Among other works he authored a threevolume account of the (...) history of education and the encyclopaedia “Almen Pædagogik”. (shrink)

Precarious Matters. The Radium Economy, Episteme of Risk and the Emergence of Tracer Technique in National SocialismFollowing the traces of radioactive material is – as scholars have recently shown – a valuable historical approach in order to evaluate the material ’factor’ of science in action. Even though the origins of materials like radium and artificial isotopes are quite different, their circulation is interconnected. A material pathway can be drawn from the radium industry to the scientific rise of artificial isotopes as (...) indicator substances in the 1930s, continuing to the building of networks by German scientists working for the war efforts. Also, this pathway reveals the role of radiation protection in establishing that material culture. Finally, the dynamics of material traces and institutional linkages is shown by the tracer work of biophysicists and radiation biologists working at the Genetic Department of the Kaiser Wilhelm Institute for Brain Research in Berlin and at the Institut de Chimie Nucléaire at Paris, which at that time was occupied by German troops. (shrink)

ArgumentThis paper brings together the history of risk and the history of DNA repair, a biological phenomenon that emerged as a research field in between molecular biology, genetics, and radiation research in the 1960s. The case of xeroderma pigmentosum (XP), an inherited hypersensitivity to UV light and, hence, a disposition to skin cancer will be the starting point to argue that, in the 1970s and 1980s, DNA repair became entangled in the creation of new models of the human body at (...) risk – what is here conceptually referred to as the vulnerability aspect of body history – and new attempts at cancer prevention and enhancement of the body associated with the new flourishing research areas of antimutagenesis and anticarcinogenesis. The aim will be to demonstrate that DNA repair created special attempts at disease prevention: molecular enhancement, seeking to identify means to increase the self-repair abilities of the body at the molecular level. Prevention in this sense meant enhancing the body's ability to cope with the environmental hazards of an already toxic world. This strategy has recently been adopted by the beauty industry, which introduced DNA care as a new target for skin care research and anti-aging formulas. (shrink)

Standard readings of Kant's ethical thought usually focus on the Groundwork, and, more particularly, in the application of the categorial imperative to any given maxim. In doing so, the standard readings do not take into account the necessary role of judgment in this process. After sketching the difference between determining and reflective judgment, and enlarging our view of Kant's ethics beyond the basic principles conveyed in Groundwork, the author discusses which may be the role of reflective judgment in Kant's moral (...) thought. As a result, an entirely different approach to the socalled applied ethics emerges. (shrink)

Die Einwände, die sich hinsichtlich der Weltprobleme gegen die Philosophie richten, sind vor allem, dass sie in ihrer Ausrichtung auf die eigenen Themen die Gegenwartsprobleme nicht zur Kenntnis nimmt, oder dass ihre Begrifflichkeit zu abstrakt ist, um der Komplexität der Wirklichkeit zu genügen. Aus diesen Gründen wird von der Philosophie ein Realitätsbezug und der Kontakt mit der Gegenwart gefordert, um zur Lösung der Weltprobleme beizutragen. Im Unterschied zu diesen Einwänden behandelt der Beitrag die Frage, ob die Philosophie selbst als ein (...) Weltproblem beurteilt werden kann. Hierfür scheinen drei Grundannahmen erforderlich zu sein: 1. der "Motor" der gegenwärtigen Globalisierungsprozesse ist die westliche Kultur, die sowohl auf den modernen Naturwissenschaften als auch auf der Idee der Menschenrechte gegründet ist. Sie erzeugt zum einen durch ihre Dynamik Probleme als Weltprobleme und definiert zum anderen, was als Weltproblem zu betrachten ist. - 2. Die Philosophie ist das geistige Fundament und der ideelle Ausdruck der westlichen Kultur. Versteht man unter "Philosophie" die institutionalisierte Praxis des Reflektierens und Begründens, die ihren Maßstab an der Rationalität hat, so ist sie hinsichtlich ihrer Genese und ihrer Geltung untrennbar mit der westlichen Kultur verbunden. - 3. Die Praxis der Philosophie, ihre Standards auf Prinzipien der Rationalität zu gründen, stimmt nicht mit den Bedingungen und Strukturen des irdischen Lebens überein. Diese Annahme widerspricht sowohl einer idealistischen Ontologie, die die natürlichen Vorgänge in rationalen Strukturen gegründet sieht, als auch einer materialistischen, die Begriffe und Theorien als Abbilder natürlicher Strukturen interpretiert. Unter diesen drei Bedingungen ist die Philosophie nicht nur mit den Weltproblemen konfrontiert, sondern muss selbst als ein Weltproblem angesehen werden. (shrink)

This study explored LaRose and Eastin's model of media attendance, within a European context. It extended the uses and gratifications paradigm within the framework of social cognitive theory by instituting new operational measures of gratifications sought, reconstructed as outcome expectations. Although the model of media attendance offers some promising steps forward in measuring media selectivity and usage, and to some extent is applicable to another context of media use, the relative importance of outcome expectancies in explaining media usage and selectivity (...) is not fully supported. (shrink)

Scheler's philosophic reflections on religious experience and on the connections between this experience and those reflections seek to found a phenomenological personalism. Hence I first delineate his conception of person via his view of phenomenology as resulting from a critique of husserl. I then elaborate scheler's conception of philosophy in terms of the intentional acts involved. After a similar elaboration of scheler's view of religion, I present his 'system of conformity' of the proper interplay of philosophy and religion. I conclude (...) by indicating why his phenomenological anthropology is not only inadequate to the foundational task assigned to it but methodologically incoherent. (shrink)

In Cultivating Citizens Dwight Allman and Michael Beaty bring together some of America's leading social and political thinkers to address the question of civic vitality in contemporary American society. The resulting volume is a serious reflection on the history of civil society and a rich and rewarding conversation about the future American civic order.